AustralieFrV1, Main, Exploration, bibRecord, 004A55

Genetic diversity and investigation of polledness in divergent goat populations using 52 088 SNPs

Identifieur interne : 004A55 ( Main/Exploration ); précédent : 004A54; suivant : 004A56

Genetic diversity and investigation of polledness in divergent goat populations using 52 088 SNPs

Auteurs : James W. Kijas [Australie] ; Judit S. Ortiz [Australie, Espagne] ; Russell Mcculloch [Australie] ; Andrew James [Australie] ; Blair Brice [Australie] ; Ben Swain [Australie] ; Gwenola Tosser-Klopp [France]

Source :

Animal Genetics [ 0268-9146 ] ; 2013-06.

RBID : ISTEX:838085ED6C54A9FA54E147A15EDC42221CB8A978

Descripteurs français

Wicri :
- topic : Consortium, Génétique, Caprin.

English descriptors

KwdEn :
- Admixture, Allele, Animal genetics, Association analysis, Association testing, Australian cashmere, Beadchip, Boer, Boer goats, Cashmere, Cashmere goats, Cattle breeds, Chromosome, Consortium, Critical interval, Deletion, Genetic, Genetic basis, Genetic distance, Genetic diversity, Genetics, Genome, Genotype, Goat, Goat breeds, Goat chromosome, Goat genome, Goat populations, Haplotype, Haplotype analysis, High levels, Horn haplotypes, Horned, Horned animals, International goat genome consortium, Intersex, Intersex animals, Intersex condition, Intersex goats, Intersex syndrome, Kijas, Locus, Pailhoux, Plink, Plo, Poll haplotypes, Polledness, Population history, Population structure, Principal components analysis, Rangeland, Rangeland animals, Rangeland goats, Rangeland population, Saanen goats, Snp, Stichting.
Teeft :
- Admixture, Allele, Animal genetics, Association analysis, Association testing, Australian cashmere, Beadchip, Boer, Boer goats, Cashmere, Cashmere goats, Cattle breeds, Chromosome, Consortium, Critical interval, Deletion, Genetic, Genetic basis, Genetic distance, Genetic diversity, Genetics, Genome, Genotype, Goat, Goat breeds, Goat chromosome, Goat genome, Goat populations, Haplotype, Haplotype analysis, High levels, Horn haplotypes, Horned, Horned animals, International goat genome consortium, Intersex, Intersex animals, Intersex condition, Intersex goats, Intersex syndrome, Kijas, Locus, Pailhoux, Plink, Plo, Poll haplotypes, Polledness, Population history, Population structure, Principal components analysis, Rangeland, Rangeland animals, Rangeland goats, Rangeland population, Saanen goats, Snp, Stichting.

Abstract

The recent availability of a genome‐wide SNP array for the goat genome dramatically increases the power to investigate aspects of genetic diversity and to conduct genome‐wide association studies in this important domestic species. We collected and analysed genotypes from 52 088 SNPs in Boer, Cashmere and Rangeland goats that had both polled and horned individuals. Principal components analysis revealed a clear genetic division between animals for each population, and model‐based clustering successfully detected evidence of admixture that matched aspects of their recorded history. For example, shared co‐ancestry was detected, suggesting Boer goats have been introgressed into the Rangeland population. Further, allele frequency data successfully tracked the altered genetic profile that has taken place after 40 years of breeding Australian Cashmere goats using the Rangeland animals as the founding population. Genome‐wide association mapping of the POLL locus revealed a strong signal on goat chromosome 1. The 769‐kb critical interval contained the polled intersex syndrome locus, confirming the genetic basis in non‐European animals is the same as identified previously in Saanen goats. Interestingly, analysis of the haplotypes carried by a small set of sex‐reversed animals, known to be associated with polledness, revealed some animals carried the wild‐type chromosome associated with the presence of horns. This suggests a more complex basis for the relationship between polledness and the intersex condition than initially thought while validating the application of the goat SNP50 BeadChip for fine‐mapping traits in goat.

Url:

https://api.istex.fr/document/838085ED6C54A9FA54E147A15EDC42221CB8A978/fulltext/pdf

DOI: 10.1111/age.12011

Affiliations:

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Le document en format XML

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<term>Association analysis</term>
<term>Association testing</term>
<term>Australian cashmere</term>
<term>Beadchip</term>
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<term>Boer goats</term>
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<term>Genotype</term>
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<term>Goat breeds</term>
<term>Goat chromosome</term>
<term>Goat genome</term>
<term>Goat populations</term>
<term>Haplotype</term>
<term>Haplotype analysis</term>
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<term>Horned animals</term>
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<term>Intersex animals</term>
<term>Intersex condition</term>
<term>Intersex goats</term>
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<term>Population history</term>
<term>Population structure</term>
<term>Principal components analysis</term>
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<term>Beadchip</term>
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<term>Boer goats</term>
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<term>Cashmere goats</term>
<term>Cattle breeds</term>
<term>Chromosome</term>
<term>Consortium</term>
<term>Critical interval</term>
<term>Deletion</term>
<term>Genetic</term>
<term>Genetic basis</term>
<term>Genetic distance</term>
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<term>Genome</term>
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<term>Goat breeds</term>
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<term>Goat genome</term>
<term>Goat populations</term>
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<front><div type="abstract">The recent availability of a genome‐wide SNP array for the goat genome dramatically increases the power to investigate aspects of genetic diversity and to conduct genome‐wide association studies in this important domestic species. We collected and analysed genotypes from 52 088 SNPs in Boer, Cashmere and Rangeland goats that had both polled and horned individuals. Principal components analysis revealed a clear genetic division between animals for each population, and model‐based clustering successfully detected evidence of admixture that matched aspects of their recorded history. For example, shared co‐ancestry was detected, suggesting Boer goats have been introgressed into the Rangeland population. Further, allele frequency data successfully tracked the altered genetic profile that has taken place after 40 years of breeding Australian Cashmere goats using the Rangeland animals as the founding population. Genome‐wide association mapping of the POLL locus revealed a strong signal on goat chromosome 1. The 769‐kb critical interval contained the polled intersex syndrome locus, confirming the genetic basis in non‐European animals is the same as identified previously in Saanen goats. Interestingly, analysis of the haplotypes carried by a small set of sex‐reversed animals, known to be associated with polledness, revealed some animals carried the wild‐type chromosome associated with the presence of horns. This suggests a more complex basis for the relationship between polledness and the intersex condition than initially thought while validating the application of the goat SNP50 BeadChip for fine‐mapping traits in goat.</div>
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Genetic diversity and investigation of polledness in divergent goat populations using 52 088 SNPs

Genetic diversity and investigation of polledness in divergent goat populations using 52 088 SNPs

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri